She was initially trained by her father, Flute Vidwan H.S. Venugopal.
Varijashree began undergoing formal training in Carnatic music under Vidhushi H. Geetha at the age of 4. She learnt a few rare compositions from Vidhushi Vasantha Srinivasan and Vidwan D.S. Srivatsa and later, took higher music lessons under Gaanakalanidhi Vidwan Salem P. Sundaresan.
She gave her first full fledged Carnatic vocal performance at the tender age of 7, at the prestigious platform of Bangalore Gayana Samaj. She was very much well appreciated by critics and music lovers.
Varijashree trained in flute playing under her father and Guru Vidwan H S Venugopal. As a flautist, Varijashree performs solo concerts and duo concerts with her father, and is a sought-after recording session artist.